年輕婦女的體重會影響HRV.
隨著體重指數BMI升高,心跳上升且HRV下降
Sztajzel J;
Golay A; Makoundou V; Lehmann TN; Barthassat V; Sievert K;
Pataky Z; Assimacopoulos-Jeannet F; Bobbioni-Harsch E
Cardiology Service, University Hospital, 24 rue Micheli-du-Crest, Geneva 4,
Switzerland. juan.sztajzel@hcuge.ch
BACKGROUND: Obesity has been
associated with significant abnormalities of the cardiac autonomic regulation.
However, the precise impact of increasing body weight on cardiac autonomic
function and the metabolic and hormonal contributors to these changes are
presently unclear. The aim of our study was to explore in subjects with increasing
values of body mass index (BMI) the alterations of cardiac autonomic function
and to establish the potential role of various metabolic and hormonal
contributors to these alterations. MATERIALS AND METHODS: We investigated time
and frequency domain heart rate variability (HRV) parameters taken from 24-h
Holter recordings, and several anthropometric, metabolic and hormonal
parameters (plasma glucose, insulin, triglycerides, free fatty acids, leptin and adiponectin) in 68 normoglycaemic and normotensive
women (mean age of 40 +/- 3 years), subdivided according to their BMI into 15
normal body weight (controls), 15 overweight, 18 obese and 20 morbidly obese.
RESULTS: Heart rate was increased and HRV was decreased in the morbidly obese
group as compared with controls. In overall population, a negative association
linked body fat mass (FM) to HRV indices. None of the metabolic and hormonal
parameters were significantly related to the HRV indices, after they were
adjusted for the body FM. CONCLUSIONS: Morbidly obese, normoglycaemic
and normotensive young women have increased HR and
low HRV, indicating an abnormal cardiac autonomic function and representing a
risk factor for adverse cardiovascular events. A decrease of HRV parameters is
associated with a progressive increase of body FM. Other metabolic and hormonal
factors, characterising obesity, do not show an
independent influence on these HRV alterations.