自律神經對免疫系統啟動發炎的程度兼具調解功能.藉由深呼吸及脂多醣誘發發炎人體實驗發現,HRV及副交感HF升高時,發炎細胞因子TNF-alpha IL-6的產量即降低

Stimulated production of proinflammatory cytokines covaries inversely with heart rate variability.

Psychosom Med.  2007; 69(8):709-16 (ISSN: 1534-7796)

Marsland AL; Gianaros PJ; Prather AA; Jennings JR; Neumann SA; Manuck SB
Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. marsland@pitt.edu

OBJECTIVE: To examine whether high-frequency heart rate variability, an indirect measure of parasympathetic (vagal) control over variations in heart rate, is associated with immune reactivity to an in vitro inflammatory challenge. Convergent evidence from the animal literature shows that the autonomic nervous system plays a key role in regulating the magnitude of immune responses to inflammatory stimuli. Signaling by the parasympathetic system inhibits the production of proinflammatory cytokines by activated monocytes/macrophages and thus decreases local and systemic inflammation. As yet, no direct human evidence links parasympathetic activity to inflammatory competence. METHODS: We examined the relationship of variations in heart rate, recorded during paced respiration, to lipopolysaccharide-induced production of the inflammatory cytokines interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-10 among a community sample of 183 healthy adults (mean age = 45 years; 59% male; 92% White, 7% African-American). RESULTS: Consistent with animal findings, higher derived estimates of vagal activity measured during paced respiration were associated with lower production of the proinflammatory cytokines TNF-alpha and IL-6 (r = -.18 to -.30), but were not related to production of the anti-inflammatory cytokine IL-10. These associations persisted after controlling for demographic and health characteristics, including age, gender, race, years of education, smoking, hypertension, and white blood cell count. CONCLUSIONS: These data provide initial human evidence that vagal activity is inversely related to inflammatory competence, raising the possibility that vagal regulation of immune reactivity may represent a pathway linking psychosocial factors to risk for inflammatory disease.